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KMID : 1123920060200020394
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Korean Journal of Oriental Physiology and Pathology
2006 Volume.20 No. 2 p.394 ~ p.403
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Effects of ChongMyung-Tang and MokguenpiChongMyung-Tang Extract on the Alzheimer’s Disease Model Induced by CT105
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Jung In-Chul
Lee Sang-Ryong
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Abstract
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This research investigated the effect of the CMT and MCMT on Alzheimer’s disease. The effects of the CMT and MCMT extract on expression of proinflammatory cytokine(, IL-6, ) in the THP-1 cell; amyloid precursor proteins(APP), acetylcholinesterase(AChE) mRNA of PC-12 cells treated with CT105; the AChE activity and the APP production of PC-12 cell lysate treated with CT105 were investigated. The CMT and MCMT extract suppressed overexpression of , IL-6, in the THP-1 cell treated by LPS; the expression of APP, AChE mRNA in PC-12 cells treated with CT105; the AChE activity and the production of APP in PC-12 cell lysate treated with CT105 significantly. This study suggest that CMT and MCMT may be effective for the prevention and treatment of Alzheimer’s disease.
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KEYWORD
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ChongMyung-Tang(CMT), MokguenpiChongMyung-Tang(MCMT), Dementia, Alzheimer’s disease, CT105, cytokine
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